Gentiopicroside improves high-fat diet-induced NAFLD in association with modulation of host serum metabolome and gut microbiome in mice
ObjectiveThe incidence of non-alcoholic fatty liver disease is increasing every year, and there is growing evidence that metabolites and intestinal bacteria play a causal role in NAFLD.Gentiopicroside, a major iridoids compound in gentian, has been reported to reduce hepatic lipid accumulation.However to date, no studies have confirmed whether the